Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. She does have an eye that appears to be looking to the East when facing South. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. I just wanted them gone and for him to feel better. I don't know if the lump came from it or something else. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. Saving money sounds great, right? The third ingredient in Simparica Trio is. No more Simperica for my dog! At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? Today started diarrhea & he has gone 5 times so far while not eating much. She also started with ear infections. Im still confused. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. She was ok for awhile, then she had a seizure and started throwing up all over the house. My dog is still having tremors 5 months after taking Simparica. She never did that before! I will NEVER give this drug to my dogs! He seems sometimes anxious and is sensitive to noise outside. He had gone to a new groomer and when he came home he had a seizure. Considerations Just like any other medication, Simparica has the potential to interact with other drugs your dog is taking. its only been about 4 days since and its been a steady decline. My dog has been on simpatico trio for 5 months .. and still got a deer tick .. He has no appetite, wont drink water and his mouth is so dry. gave this to my dog three different times. We did get a little symptom improvement from prednisone if they are having other neurological issues. We did not make the connection until today. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. He does well on Simparica trio and also has the Lyme shot ? Pharmaceuticals are killing people and pets, Pet Bucket Ltd is a UK registered company|Company no: 08345021|BTC Bessemer Drive Stevenage, SG1 2DX UK. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. Or has it been too many doses ? She didn't make it to the next day and died overnight. Which Type of Dog Fence Is Right For Your Pet? As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. In other words, they can make it easier to have a seizure in susceptible dogs. The results are fatal for fleas and ticks but safe for mammals such as your dog. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. She keeps running through the house as though looking for something. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. I am worried! Took him back to the vet. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. After reading theses comments I started looking into SIMPARICA TRIO. This junk needs to be pulled from the market. Called his vet and they gave no information. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. The office girl not the vet said if it my dog threw up within one hour after eating her pill - then it is safe to give her another one. I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. Four months of vet visits because of one dose of field tested safe Simparica. He is 5 months old. FREE shipping and the BEST customer service! You keep your dog cages? But today, after he ate dinner and drank water, it all came back up. It could be a coincidence but seems too coincidental. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! Random vomitting is no fun either. It just dawned on me to look and see if this drug might be the reason. Seizures are going on two hours.. its been 2 weeks .We just had a blood draw done again and they are still high. Today really soft stool (not diarrhea but close). Pyrantel Pamoate was first approved in 1977 for the treatment and . Really? I'll continue to watch her. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). When he lays in the sun you can see the bumps under his skin. The Vet's are so busy that even if you can get in you don't get anywhere. I hope it is better. Somedays he will have 2 and then he will go for a couple days without having any issues. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. By Tuesday evening symptoms came back worse. It comes as the first choice when prescribing a treatment due to its liver flavor. It wasnt even four hours later all four of my dogs were throwing up, lethargic sick as hell didnt think they were gonna make it three pulled out my little Mr. weenie. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. I called the vet and they said it was likely brought on by stress. We are experiencing the same thing. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. He was in excellent health prior to this incident. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). I'm besides myself. He seems back to his normal self and playing with his toys, but we will not continue the following doses! I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. Sound familiar? I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Yea so what about the 10 percent? He has been on just Simparica with no problems. Hi, Im having similar issues. If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. Doubtful our dog will be given Simparica again. She had a beautiful coat of fur. Her blood work came back fine. I just wanted to get another opinion before we move forward. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. I know Dukes problems were from this medicine, and it upsets me that my vet told me that this medicine was safe! Any response from the company? I gave him this medication last Thursday. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. So bad that the FDA made them put a huge warning now on the package. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. Its Sunday night and still vomiting. And it looks like the liver and/or the kidney will not take it too. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! I gave my 15 year old dog this medicine. Since she is young, the vet started us with Keppra. Is it effective? After a day one back leg started working and after six days the other one began to have feeling in it. Not to worry you, and I hope yours is different outcome! On 08/06 she threw up. I have had German Shepherds for 40 yrs. The excerpts below from the manufacturers' Prescribing . Puppy is having seizures and has aspirated pneumonia. Simparica and Simparica Trio are available by prescription only. Was checking out before using . A week after I lost her I got COVID and was in the hospital for 20 days. I just hope he makes it to his life expectancy . Please think these things through before subjecting your pet to internal insecticides. Don't risk the well-being of your beloved dog just because something is more convenient. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. I will not be giving him simparica again. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. I would notice he gets super tired walking and would go limp in my arms. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. They must get some kind of monetary bonus for only selling Simparica. I hope the best for you and dog, I know its a tough time. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. So we went home with her on steroids and more antibiotics and denamrin for liver. Not grass grazing either. Two months no flare up no more scabs and loosing hair. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. Eyes roll back. Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. The whole packet is going in the bin !! I have reached out to the company but one email bounced and the other was an online form. She has what is called knuckling. This medication is generally well tolerated in most pets. Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). Went to a different vet, within minutes he found a large mass on my Poms abdomen. I threw him his ball and he actually was interested in it. Especially, Camelia who lost her furbaby because of a seizure that was apparently brought on by this medication. But im 99% sure the simparica is what caused it. I wish I had read these comments before giving this to my Frenchie. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Something I will never know what happened to herIf I knew this would kill her I would never had used it. I feel so sad for you Camelia. I gave my 1 year old collie cross Simparica flea and tick medication. Her Liver enzymes were also through the roof. Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. She went on 2 antibiotics, and medicated baths twice a week. He wasnt throwing up at all until he received this medication. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. 300+ Cute Cat Names for Every Kind of Kitty. My beautiful boxer lost his appetite after just one dose of Simparica. I just gave my Matty her first dose. Stopped meds and he has had 3 more seizures since. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. The diarrhea also went away yesterday evening. I have to turn him around and lead him away. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. Still waiting on the vet and waiting to talk to ASPCA poison control. He woke up and seemed much brighter. I am almost 100% sure that all of these symptoms are caused by this medication. The next morning, she had uncontrollable tremors and could not walk without falling down. Initially I noticed minor tremors and twitching when he slept or was just relaxing. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. It didnt even occur to me it could be the drug as my doctor just gave individual pills and I didnt get to read side effects. It has been five days and the diarrhea started on day 2. After being ingested by a dog, sarolaner is distributed throughout the body. I definitely will not poison her with this garbage anymore. I must admit that I am pretty nervous about it, but we shall see. This is an eye opener for me! Dogs Naturally Market is a good source to check out. It went away, I thought the diarrhea was from some of the junk she eats off of the ground. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. I am continuing to recover at home and have to use an oxygen tank. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! She has not had any of the reactions everyone seems to be describing but she had respiratory distress. Has anyone experienced cardiac issues while under anesthesia on this medication? Thursday morning was an awful beginning of the day for our boy. Im going to another vet and discontinuing simparica. In some dogs, Simparica may cause abnormal neurologic signs such as: Tremors and Seizures. My dogs have been throwing up since then and I could not for the life of me figure out why. Then she lost control of her legs and couldn't walk or stand. This is lethal medication for dogs and should be taken off the market now. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog one month before the fleas become active. He has all the symptoms Eveyone is describing. I will never give him this drug again. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Im throwing away the remaining 5 pills and going back to a topical medicine. Im trying to understand how. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. Blood work + urine sample. Before sharing sensitive information, make sure you're on a federal government site. Oh Lord, back to finding another vet. I have a vet appointment tomorrow to figure it out. How is your dog now? So scary. The FDA continues to monitor adverse drug event reports for these products and encourages pet owners and veterinarians to report adverse drug events. Possible side effects: Vomiting, diarrhea (if these . We wont be using this medicine ever again! Gave our 23 month old Black Lab. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. My vet recommended the tablet to save on monthly costs for flea and tick treatment. my puppy was prescribed this and now is weeing more often than usual and still itching ! Hello! This is just another reason to follow your vet's recommendations for annual physical exams and tests. The exact same thing is happening to my dog now. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Were now into day 2 no changes except add a continuous walking into the next room turn around come back sit down just to repeat several more times. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : Some adverse reactions to Simparica include tremors, decreased awareness of body movement, loss of control over bodily movements, problems blinking, and/or seizures. He said it would take care of ticks and Trifexis doesn't. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. I made some chicken and rice. These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite I started thinking about his history. She seems to have aged five years since T-Day. I got my dog Josey up to let him out to pee. Hello! Some dogs improve, some don't, not a clear answer why. He has never done this, and when I heard it and woke up he couldn't stop. Thank you to all of you posting and I hope all of your babies are doing well. He just couldn't stand good, he constantly shakes his head. Im seeing an improvement in my dog, and am crossing fingers that this continues! Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. Has odd agitated swallowing when not eating anything. I gave my yellow Lab, Sophie, her first Simperica trio. But you can use a collar or topical for ticks if needed. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. Weighing your dog regularly will ensure that you are using the correct product size. Im going to keep a close watch on him over the next few days. Everything else in his environment, world has remained the same. Her protein levels dropped to almost nothing and stomach filled with fluid. Hoping we dont have any more issues and will not be giving this again. This is whats happening to our pup, can you please tell me how long it lasted? My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. Benefits: Each tablet provides a full month of protection against fleas and ticks. The main side effect of Simparica Trio is the risk of heartworm disease in dogs. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. He has horrible water like stools. Was not too excited about it, and I really should've declined it. Like many of you, I was unsure about the cause. And then when we finally stop for the evening - she crashes. Trifexis and Simparica are available only with a prescription from your veterinarian. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. If undiagnosed he would have died. Then the following week 1 pill every other day . After second pill, weve notice he has been a bit down for a couple days. It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. He just isnt himself. Two weeks after I made the post above our girl started having seizures and we had to put her down. First month, the one threw up, same thing second month. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. May not be from this med but too strange to at least not think about it. Our dog was killed by this poison within 15 hours after taking one dose. . I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. around 12 years She grabs and won't let go. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. Thank you all so much for this thread and giving me hope. However, doing nothing is better than giving her the Simparica. Head bobbling and hind legs unable to support her - as if she were really drunk. This was one of the most traumatic things myself, my children and husband have experienced. Them I took him to a vet for check up and to my horror, he has fleas and a tick. The next day Bellas stools were quite soft but still had some structure. I'm at a loss We had same issues. Then I saw this and realized. That sh-t should be banned. Simparica is pretty new in England and it seems they are trialling it. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. He licks his lips all the time? The vet does not feel it is due to Simparica but i think it could be. So sorry! Can my dog still get Lyme disease from a tick that was in him. Hoping for a good outcome!!! Simparica can cause ataxia, which is the official name for loss of body control. For all symptoms to be reversed & to return to normal . It has been 20 days since I gave her the prescribed dose of Simparica. Thank you for this. my vet recommended this for both my yorkies. Please do NOT use it!! I hope we get to the bottom of it as this is not fun. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Exhibiting problems and i really hope that all of these symptoms are caused by this poison within 15 hours taking! The couch and was extremely hesitant to go up the steps or individual doses ) him around and him. Least not think about it best for you and dog, i know Dukes problems from! 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